DNAdamagecheckpoint

The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or ...

由 M Laiho 著作 · 2003 · 被引用 75 次 — Abstract. DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss ...

由 T Weinert 著作 · 1998 · 被引用 348 次 — Thus, following blocks to DNA replication or damage, their own synthesis is derepressed, creating a negative feedback loop. This feedback loop may dampen the ...

The G2/M DNA damage checkpoint serves to prevent the cell from entering mitosis (M-phase) with genomic DNA damage. Specifically, the activity of the Cyclin B- ...

由 BBS Zhou 著作 · 2000 · 被引用 4221 次 — DNA damage checkpoints were initially defined as non-essential regulatory pathways that control the ability of cells to arrest the cell cycle in ...

由 CQX Yam 著作 · 2022 · 被引用 9 次 — In vertebrate cells, G2/M DNA damage checkpoint halts cell cycle progression predominantly by inhibiting the regulatory network responsible for ...

DNA damage checkpoints initially were defined as regulatory pathways that control the ability of cells to arrest the cell cycle in response to DNA damage, ...

The DNA damage checkpoint provides the cell with an opportunity to stall cell division such that an effective DNA repair effort can be mounted. Blocking cells ...