DNAdamagecheckpoint

TheG2-MDNAdamagecheckpointisanimportantcellcyclecheckpointineukaryoticorganismsthatensuresthatcellsdon'tinitiatemitosisuntildamagedor ...,由HLSmith著作·2020·被引用202次—LossofG1checkpointcontroliscommonincancerthroughTP53,ATMmutations,RblossorcyclinEoverexpression,providingastronger ...,由PPizzul著作·2022·被引用23次—Inbuddingyeast,asingleunrepairableDSBissufficienttoinduceastrongcheckpointacti...

G2

The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or ...

DNA damage checkpoint kinases in cancer

由 HL Smith 著作 · 2020 · 被引用 202 次 — Loss of G1 checkpoint control is common in cancer through TP53, ATM mutations, Rb loss or cyclin E overexpression, providing a stronger ...

The DNA damage checkpoint

由 P Pizzul 著作 · 2022 · 被引用 23 次 — In budding yeast, a single unrepairable DSB is sufficient to induce a strong checkpoint activation that persist approximately a dozen hours, after which cells ...

The DNA damage response

由 BBS Zhou 著作 · 2000 · 被引用 4288 次 — DNA damage checkpoints were initially defined as non-essential regulatory pathways that control the ability of cells to arrest the cell cycle in ...

Activation of the DNA damage checkpoint and genomic ...

由 VG Gorgoulis 著作 · 2005 · 被引用 2406 次 — DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their inactivation remains ...

DNA damage checkpoint execution and the rules of its ...

由 CQX Yam 著作 · 2022 · 被引用 15 次 — Here, we discuss the DNA damage checkpoint, the mitotic networks it inhibits to prevent segregation of damaged chromosomes and the strategies ...

DNA Damage Checkpoint

The DNA damage checkpoint provides the cell with an opportunity to stall cell division such that an effective DNA repair effort can be mounted.